Glutamatergic Dysfunction In Schizophrenia, Автор: JM Stone · 2011 · Цитируется: 102 — Growing evidence for glutamate abnormalities in schizophrenia support the development of novel antipsychotic agents targeting this system. Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia. Автор: EHX Thomas · 2017 · Цитируется: 57 — The glutamatergic system appears to contribute to the cognitive deficits in schizophrenia, whereby different parts of the pathway are associated with different Abnormalities of the glutamate system are widely recognized to be involved in the pathophysiology of schizophrenia, though the exact mechanism is still Автор: SR Hirsch · 1997 · Цитируется: 158 — There is mounting evidence of a glutamate dysfunction in schizophrenia, as suggested by the fact that schizophrenia and phencyclidine psychosis are similar Автор: PA Gargiulo · 2014 · Цитируется: 44 — An increase in glutamatergic transmission fully enhances cognition in the tasks used. Neurosci Lett. , hypofrontality) in schizophrenia remain unclear. The Автор: TL Schwartz · 2012 · Цитируется: 305 — This now generates psychotic positive symptoms of schizophrenia. Neurosci Lett The glutamate hypothesis for schizophrenia asserts that glutamatergic dysfunction is a key causal contributor to both the pathogenesis and Автор: G Tsai · 1998 · Цитируется: 99 — Normal cerebrospinal fluid and brain glutamate levels in schizophrenia do not support the hypothesis of glutamatergic neuronal dysfunction. Автор: JM Stone · 2007 · Цитируется: 569 — We consider the case for glutamatergic excitotoxicity as a key process in the development and progression of schizophrenia, and suggest ways in which glutamate Автор: JR Bustillo · 2011 · Цитируется: 132 — Although not reduced in schizophrenia as a group, lower Glx levels correlates with impaired cognition in the illness. Автор: A Egerton · 2017 · Цитируется: 113 — Schizophrenia is associated with brain glutamate dysfunction, but it is currently unclear whether antipsychotic administration can reduce the extent of The pathogenesis of schizophrenia may be caused by dysfunction of NMDARs or of the glutamatergic system in general. Автор: F Iasevoli · 2014 · Цитируется: 67 — Glutamatergic dysfunction has long been suggested to involve an imbalance in the amount and distribution pattern of glutamate receptors in key cerebral areas. Dopaminergic D-2 antagonists partially improved cognition. Several lines of evidence suggest that schizophrenia is associated with deficits in glutamatergic transmission at the N-methyl-d-aspartate (NMDA) receptors. This abnormal GLU-GABA-GLU-DA neurocircuit loop now may explain the NMDA receptor hypofunction Glutamate levels were found to be significantly higher in the brains of teens at high genetic risk for schizophrenia than in the brains of teens not at such An excess of the brain neurotransmitter glutamate may cause a transition to psychosis in people at risk for schizophrenia. Автор: EMP Poels · 2014 · Цитируется: 219 — Two studies measured glutamatergic levels of patients with SCZ in the superior or lateral temporal lobe. The main technique available for assessing central Автор: RD Paz · 2008 · Цитируется: 188 — The underlying cellular mechanisms leading to frontal cortical hypofunction (i. Автор: N Zhand · 2019 · Цитируется: 17 — Over the past two decades, accumulating evidence has implicated the role of glutamatergic dysfunction in the pathophysiology of schizophrenia. Both studies reported no differences in Glx levels Автор: JW Olney · 1995 · Цитируется: 2269 — Normal cerebrospinal fluid and brain glutamate levels in schizophrenia do not support the hypothesis of glutamatergic neuronal dysfunction . Our results We consider the case for glutamatergic excitotoxicity as a key process in the development and progression of schizophrenia, and suggest ways in which glutamate Автор: J Kantrowitz · 2012 · Цитируется: 203 — The glutamatergic hypothesis has since been expanded to include a potential role for dysfunction at other subtypes of glutamatergic receptors, as well as Автор: M Haaf · 2018 · Цитируется: 57 — The glutamate hypothesis of schizophrenia is based on findings of increased symptom severity in patients with schizophrenia and the emergence of schizophrenia- . Effects of NMDAR Автор: RA Bressan · 2003 · Цитируется: 39 — Although dopamine dysfunction in schizophrenia is unequivocal, there are many evidences suggesting the involvement of the glutamatergic system. Автор: AO Kruse · 2022 · Цитируется: 216 — There is little doubt that brain glutamatergic abnormalities are present in schizophrenia and that some of these are related to the etiology of the illness. e. This paper Автор: JT Coyle · 1996 · Цитируется: 764 — Examines the growing evidence that dysfunction of corticolimbic glutamatergic neurotransmission may contribute to or account for the manifestations of Abnormal glutamatergic neurotransmission is strongly implicated in the pathophysiology of schizophrenia. uib, mf, g5sa, 30, bxn345, yobd, a4qpcb, rpuqt, czmuh, vk,